AskDefine | Define transamination

Dictionary Definition



1 the process of transposing an amino group within a chemical compound
2 the process of transfering an amino group from one compound to another

User Contributed Dictionary



  1. the transfer of an amino group from an amino acid to another molecule

Related terms

Extensive Definition

Transamination (or aminotransfer) is the reaction between an amino acid and an alpha-keto acid. The amino group is transferred from the former to the latter; this results in the amino acid being converted to the corresponding α-keto acid, while the reactant α-keto acid is converted to the corresponding amino acid (if the amino group is removed from an amino acid, an α-keto acid is left behind).
Transamination in biochemistry is accomplished by enzymes called transaminases or aminotransferases. The human body synthesizes the 10 non-essential amino acids and transamination is the process by which most of these syntheses occur. The chirality of an amino acid is determined during transamination. This reaction uses the coenzyme PLP, and is considered to be a kinetically perfect reaction. The product of transamination reactions depend on the availability of alpha-keto acids. The products usually are either alanine, aspartate or glutamate, since their corresponding alpha-keto acids are produced through metabolism of fuels.

See also

transamination in Czech: Transaminace
transamination in German: Transaminierung
transamination in French: Transamination
transamination in Japanese: アミノ基転移
transamination in Chinese: 转氨基作用
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